Meaning and history
From a Latin name derived from serenus, meaning “clear, tranquil, serene,” Séréna was borne by an obscure early saint and later appeared in Edmund Spenser’s The Faerie Queene (1590); a notable modern bearer is tennis player Serena Williams (born 1981).
Serena rose from #331 to #325 for girls between 2024 and 2025. Its highest annual birth count came in 2000, with 1,504 births.