Meaning and history
Alyssa is a variant of Alicia, and its spelling was probably influenced by the alyssum flower, whose name comes from Greek ἀ (a), a negative prefix, plus λύσσα (lyssa), meaning “madness” or “rabies,” because the plant was once believed to cure madness.
Alyssa moved from #399 to #453 for girls between 2024 and 2025. Its highest annual birth count came in 1999, with 14,036 births.